pico-Pronunciation: /ˈpiːkəʊ, ˈpʌɪkəʊ/Definition of pico- combining form (used in units of measurement) denoting a factor of 10−12:picosecond very small:picornavirusOrigin:from Spanish pico, literally 'beak, peak, little bit'pico- in other Oxford dictionaries Definition of pico- in the US English dictionary