extrapyramidalPronunciation: /ˌɛkstrəpɪˈramɪd(ə)l/Definition of extrapyramidal adjective Anatomy & Medicine relating to or denoting motor nerves that descend from the cortex to the spine but are not part of the pyramidal system:extrapyramidal symptomsextrapyramidal in other Oxford dictionaries Definition of extrapyramidal in the US English dictionary