Lyme diseasePronunciation: /lʌɪm/Definition of Lyme disease noun [mass noun] a form of arthritis caused by bacteria that are transmitted by ticks. Lyme disease is caused by the spirochaete Borrelia burgdorferi Origin: 1970s: named after Lyme, a town in Connecticut, US, where an outbreak occurredLyme disease in other Oxford dictionaries Definition of Lyme disease in the US English dictionary