zidovudine Syllabification: (zi·do·vu·dine)Pronunciation: /zīˈdävyəˌdēn, zə-, -ˈdō-/Definition of zidovudine noun Medicine an antiviral drug used in the treatment of AIDS. It slows the growth of HIV infection in the body, but is not curative. A thymidine derivative; chemical formula: C10H13N5O4 Origin: 1980s: arbitrary alteration of azidothymidinezidovudine in other Oxford dictionaries Definition of zidovudine in the British & World English dictionary