trimethoprim Syllabification: (tri·meth·o·prim)Pronunciation: /trīˈmeTHəˌprim/Definition of trimethoprim noun Medicine a synthetic antibiotic used to treat malaria and respiratory and urinary infections (usually in conjunction with a sulfonamide). Origin: 1960s: from trimeth(yl) + o(xy-) + p(y)rim(idine)trimethoprim in other Oxford dictionaries Definition of trimethoprim in the British & World English dictionary