tosyl Syllabification: (tos·yl)Pronunciation: /ˈtäsəl/Definition of tosyl noun [as modifier] Chemistry of or denoting the toluene-4-sulphonyl radical SO2C6H4CH3, used in organic synthesis. Origin: 1930s: from German, from to(luol) and s(ulphon)yltosyl in other Oxford dictionaries Definition of tosyl in the British & World English dictionary