thiopental Syllabification: (thi·o·pen·tal)Pronunciation: /ˌTHī-ōˈpenˌtal, -tôl/Definition of thiopental noun MedicineNorth American a sulfur-containing barbiturate drug used as a general anesthetic and hypnotic, and (reputedly) as a truth serum. Origin: 1940s: from thio- + a contraction of pentobarbitalthiopental in other Oxford dictionaries Definition of thiopental in the British & World English dictionary