tachyphylaxis Syllabification: (tach·y·phy·lax·is)Pronunciation: /ˌtakəfiˈlaksis/Definition of tachyphylaxis noun Medicine rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system. tachyphylaxis in other Oxford dictionaries Definition of tachyphylaxis in the British & World English dictionary