sympatholytic Syllabification: (sym·pa·tho·lyt·ic)Pronunciation: /ˌsimpəTHōˈlitik/ MedicineDefinition of sympatholytic adjective (of a drug) antagonistic to or inhibiting the transmission of nerve impulses in the sympathetic nervous system. noun a sympatholytic drug, often used in the treatment of high blood pressure. sympatholytic in other Oxford dictionaries Definition of sympatholytic in the British & World English dictionary