sulfamethoxazole Syllabification: (sul·fa·meth·ox·a·zole)Pronunciation: /ˌsəlfəmeˈTHäksəˌzōl/ (chiefly British also sulphamethoxazole)Definition of sulfamethoxazole noun Medicine a sulfonamide antibiotic used to treat respiratory and urinary tract infections, and as a component of the preparation co-trimoxazole. sulfamethoxazole in other Oxford dictionaries Definition of sulfamethoxazole in the British & World English dictionary