sclerotome Syllabification: (scle·ro·tome)Pronunciation: /ˈskli(ə)rəˌtōm, ˈskler-/Definition of sclerotome noun Embryology the part of each somite in a vertebrate embryo giving rise to bone or other skeletal tissue. Compare with dermatome, myotome.sclerotome in other Oxford dictionaries Definition of sclerotome in the British & World English dictionary