recombination Syllabification: (re·com·bi·na·tion)Pronunciation: /rēˌkämbəˈnāSHən/Definition of recombination noun the process of recombining things. Genetics the rearrangement of genetic material, especially by crossing over in chromosomes or by the artificial joining of segments of DNA from different organisms. recombination in other Oxford dictionaries Definition of recombination in the British & World English dictionary