pyridostigmine Syllabification: (pyr·i·do·stig·mine)Pronunciation: /ˌpiridōˈstigˌmēn/Definition of pyridostigmine noun Medicine a synthetic compound related to neostigmine, with similar but weaker and longer-acting effects. Origin: 1950s: blend of pyridine and neostigminepyridostigmine in other Oxford dictionaries Definition of pyridostigmine in the British & World English dictionary