pyoderma Syllabification: (py·o·der·ma)Pronunciation: /ˌpīəˈdərmə/Definition of pyoderma noun Medicine a skin infection with formation of pus. Origin: 1930s: from Greek puo- (from puon 'pus') + derma 'skin'pyoderma in other Oxford dictionaries Definition of pyoderma in the British & World English dictionary