psychosomatic Syllabification: (psy·cho·so·mat·ic)Pronunciation: /ˌsīkōsəˈmatik/Translate psychosomatic | into Italian | into Spanish Definition of psychosomatic adjective (of a physical illness or other condition) caused or aggravated by a mental factor such as internal conflict or stress:her doctor was convinced that most of Edith’s problems were psychosomatic of or relating to the interaction of mind and body. Derivatives psychosomaticallyPronunciation: /-ik(ə)lē/ adverb psychosomatic in other Oxford dictionaries Definition of psychosomatic in the British & World English dictionary