propoxyphene Syllabification: (pro·pox·y·phene)Pronunciation: /prōˈpäksəˌfēn/Definition of propoxyphene noun Medicine a synthetic compound chemically related to methadone, used as a mild narcotic analgesic. Origin: 1950s: from propyl + oxy-2 + -phene (from phenyl)propoxyphene in other Oxford dictionaries Definition of propoxyphene in the British & World English dictionary