probenecid Syllabification: (pro·ben·e·cid)Pronunciation: /prōˈbenəsid/Definition of probenecid noun Medicine a synthetic compound that promotes increased excretion of uric acid and is used to treat gout. Chemical formula C13H19NO4S Origin: 1950s: from pro(pyl) + ben(zoic) + -e- + (a)cidprobenecid in other Oxford dictionaries Definition of probenecid in the British & World English dictionary