prefrontal Syllabification: (pre·fron·tal)Pronunciation: /prēˈfrəntl/Definition of prefrontal adjective [attributive] 1 Anatomy in or relating to the foremost part of the frontal lobe of the brain:the prefrontal cortex 2 Zoology relating to or denoting a bone in front of the eye socket in some lower vertebrates (equivalent to part of the human ethmoid bone). noun Zoology a prefrontal bone. prefrontal in other Oxford dictionaries Definition of prefrontal in the British & World English dictionary