paracrine Syllabification: (par·a·crine)Pronunciation: /ˈparəkrin/Definition of paracrine adjective Physiology of, relating to, or denoting a hormone that has effect only in the vicinity of the gland secreting it. Origin: 1970s: from para-1 'beside' + a shortened form of endocrine or exocrineparacrine in other Oxford dictionaries Definition of paracrine in the British & World English dictionary