ostomy Syllabification: (os·to·my)Pronunciation: /ˈästəmi/Definition of ostomy noun (plural ostomies) Medicine an artificial opening in an organ of the body, created during an operation such as a colostomy, ileostomy, or gastrostomy; a stoma. Origin: 1950s: from colostomy, ileostomy, etc.ostomy in other Oxford dictionaries Definition of ostomy in the British & World English dictionary