nystatin Syllabification: (nys·ta·tin)Pronunciation: /ˈnistətin, ˈnī-/Definition of nystatin noun an antibiotic used chiefly to treat fungal infections. This antibiotic is obtained from the bacterium Streptomyces noursei Origin: 1950s: from N(ew) Y(ork) Stat(e) (where it was developed) + -in1nystatin in other Oxford dictionaries Definition of nystatin in the British & World English dictionary