nifedipine Syllabification: (ni·fed·i·pine)Pronunciation: /nīˈfedəpēn/Definition of nifedipine noun Medicine a synthetic compound that acts as a calcium antagonist and is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Origin: 1970s: from ni(tro-) + fe (alteration of phenyl) + di-1 + p(yrid)ine, elements of the systematic namenifedipine in other Oxford dictionaries Definition of nifedipine in the British & World English dictionary