monofilament Syllabification: (mon·o·fil·a·ment)Pronunciation: /ˌmänəˈfiləmənt/ (also monofil /ˈmänəˌfil/)Definition of monofilament noun a single strand of man-made fiber. a type of fishing line using a single strand of man-made fiber. monofilament in other Oxford dictionaries Definition of monofilament in the British & World English dictionary