methicillin Syllabification: (meth·i·cil·lin)Pronunciation: /ˌmeTHəˈsilən/Definition of methicillin noun Medicine a semisynthetic form of penicillin used against staphylococci that produce penicillinase. Origin: 1960s: from meth(yl) and (pen)icillinmethicillin in other Oxford dictionaries Definition of methicillin in the British & World English dictionary