mesosphere Syllabification: (mes·o·sphere)Pronunciation: /ˈmezəˌsfi(ə)r, ˈmē-/Definition of mesosphere noun the region of the earth’s atmosphere above the stratosphere and below the thermosphere, between about 30 and 50 miles (50 and 80 km) in altitude. Derivatives mesosphericPronunciation: /ˌmezəˈsfi(ə)rik, ˌmē-/ adjective mesosphere in other Oxford dictionaries Definition of mesosphere in the British & World English dictionary