mescal Syllabification: (mes·cal)Pronunciation: /meˈskal, mə-/Definition of mescal noun 1another term for maguey. an intoxicating liquor distilled from the sap of an agave. Compare with tequila, pulque. 2another term for peyote.Origin: early 18th century: from Spanish mezcal, from Nahuatl mexcallimescal in other Oxford dictionaries Definition of mescal in the British & World English dictionary