lysergic acid Syllabification: (ly·ser·gic ac·id)Pronunciation: /līˈsərjik, li-/Definition of lysergic acid noun Chemistry a crystalline compound prepared from natural ergot alkaloids or synthetically, from which the drug LSD ( lysergic acid diethylamide) can be made. A tetracyclic acid; chemical formula: C16H16N2O2 Origin: 1930s: lysergic from (hydro)lys(is) + erg(ot) + -iclysergic acid in other Oxford dictionaries Definition of lysergic acid in the British & World English dictionary