lupus Syllabification: (lu·pus)Pronunciation: /ˈlo͞opəs/Definition of lupus noun any of various diseases or conditions marked by inflammation of the skin, especially lupus vulgaris or lupus erythematosus. Derivatives lupoidPronunciation: /-ˌpoid/ adjective lupousPronunciation: /-pəs/ adjective Origin: late 16th century: from Latin, literally 'wolf'lupus in other Oxford dictionaries Definition of lupus in the British & World English dictionary