hypothyroidism Syllabification: (hy·po·thy·roid·ism)Pronunciation: /ˌhīpōˈTHīroiˌdizəm/Definition of hypothyroidism noun Medicine abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development in children and adults. Derivatives hypothyroid noun & adjective hypothyroidism in other Oxford dictionaries Definition of hypothyroidism in the British & World English dictionary