handshake Syllabification: (hand·shake)Pronunciation: /ˈhan(d)ˌSHāk/Translate handshake | into French | into German | into Italian | into Spanish Definition of handshake noun an act of shaking a person’s hand with one’s own, used as a greeting or to finalize an agreement. a person’s particular way of doing this:her handshake was warm and firm Computing an exchange of standardized signals between devices in a computer network regulating the transfer of data. Derivatives handshakingPronunciation: /-SHākiNG/ noun handshake in other Oxford dictionaries Definition of handshake in the British & World English dictionary