glucagon Syllabification: (glu·ca·gon)Pronunciation: /ˈglo͞okəˌgän/Definition of glucagon noun Biochemistry a hormone formed in the pancreas that promotes the breakdown of glycogen to glucose in the liver. Origin: 1920s: from Greek glukus 'sweet' + agōn 'leading, bringing'glucagon in other Oxford dictionaries Definition of glucagon in the British & World English dictionary