fluoride Syllabification: (fluor·ide)Pronunciation: /ˈflo͝orˌīd, ˈflôr-/Translate fluoride | into French | into German | into Italian | into Spanish Definition of fluoride noun Chemistry a compound of fluorine with another element or group, especially a salt of the anion F or an organic compound with fluorine bonded to an alkyl group. sodium fluoride or another fluorine-containing salt added to water supplies or toothpaste in order to reduce tooth decay. Origin: early 19th century: from fluorine + -ideRemember that fluoride begins with fluor-.fluoride in other Oxford dictionaries Definition of fluoride in the British & World English dictionary