encephalization Syllabification: (en·ceph·a·li·za·tion)Pronunciation: /enˌsefəliˈzāSHən/Definition of encephalization noun Zoology an evolutionary increase in the complexity or relative size of the brain, involving a shift of function from noncortical parts of the brain to the cortex. encephalization in other Oxford dictionaries Definition of encephalization in the British & World English dictionary