doxycycline Syllabification: (dox·y·cy·cline)Pronunciation: /ˌdäksēˈsīklēn/Definition of doxycycline noun Medicine a broad-spectrum antibiotic of the tetracycline group, which has a long half-life in the body. Origin: 1960s: from d(e)oxy- + tetracyclinedoxycycline in other Oxford dictionaries Definition of doxycycline in the British & World English dictionary