cyclosporine Syllabification: (cy·clo·spo·rine)Pronunciation: /ˌsīkləˈspôrin, -ˌēn/ (also cyclosporin A, cyclosporin)Definition of cyclosporine noun Medicine a drug with immunosuppressive properties used to prevent the rejection of grafts and transplants. A cyclic peptide, it is obtained from a fungus. This drug is obtained from the fungus Trichoderma polysporum Origin: 1970s: from cyclo- + -sporin (from Latin spora 'spore') + -in1cyclosporine in other Oxford dictionaries Definition of cyclosporine in the British & World English dictionary