cryoglobulin Syllabification: (cry·o·glob·u·lin)Pronunciation: /ˌkrīəˈgläbyələn/Definition of cryoglobulin noun Biochemistry a protein that occurs in the blood in certain disorders. It can be precipitated out of solution below 10°C, causing obstruction in the fingers and toes. cryoglobulin in other Oxford dictionaries Definition of cryoglobulin in the British & World English dictionary