colchicine Syllabification: (col·chi·cine)Pronunciation: /ˈkälCHəˌsēn, ˈkälkə-/Definition of colchicine noun Chemistry a yellow compound present in the corms of colchicums, used to relieve pain in cases of gout. An alkaloid; chemical formula: C22H25NO6 colchicine in other Oxford dictionaries Definition of colchicine in the British & World English dictionary