chymotrypsin Syllabification: (chy·mo·tryp·sin)Pronunciation: /ˌkīmōˈtripsən/Definition of chymotrypsin noun Biochemistry a digestive enzyme that breaks down proteins in the small intestine. It is secreted by the pancreas and converted into an active form by trypsin. Origin: 1930s: from chymo- (combining form of chyme) + trypsinchymotrypsin in other Oxford dictionaries Definition of chymotrypsin in the British & World English dictionary