cholinergic Syllabification: (cho·lin·er·gic)Pronunciation: /ˌkōləˈnərjik/Definition of cholinergic adjective Physiology 1relating to or denoting nerve cells in which acetylcholine acts as a neurotransmitter. Contrasted with adrenergic. 2releasing or responding to acetylcholine. Origin: 1930s: from choline + Greek ergon 'work' + -iccholinergic in other Oxford dictionaries Definition of cholinergic in the British & World English dictionary