bulla Syllabification: (bul·la)Pronunciation: /ˈbo͝olə/Definition of bulla noun (plural bullae /ˈbo͝olē/) 1 Medicine a bubblelike cavity filled with air or fluid, in particular. a large blister containing serous fluid. an abnormal air-filled cavity in the lung. [ early 19th century] 2 Anatomy a rounded prominence. [ mid 19th century] 3a round seal attached to a papal bull, typically made of lead. [ Middle English]Origin:Latin, literally 'bubble'bulla in other Oxford dictionaries Definition of bulla in the British & World English dictionary