antispasmodic Syllabification: (an·ti·spas·mod·ic)Pronunciation: /ˌantēspazˈmätik, ˌantī-/Definition of antispasmodic adjective (chiefly of a drug) used to relieve spasm of involuntary muscle. noun an antispasmodic drug. antispasmodic in other Oxford dictionaries Definition of antispasmodic in the British & World English dictionary