antiretroviral Syllabification: (an·ti·re·tro·vi·ral)Pronunciation: /ˌantēˌretrōˈvīrəl, ˌantī-/Translate antiretroviral | into Italian | into Spanish Definition of antiretroviral adjective working against or targeted against retroviruses, especially HIV:antiretroviral therapy noun an antiretroviral drug. antiretroviral in other Oxford dictionaries Definition of antiretroviral in the British & World English dictionary