antipruritic Syllabification: (an·ti·pru·rit·ic)Pronunciation: /ˌantēprəˈritik, ˌantī-/Definition of antipruritic adjective [attributive] (chiefly of a drug) used to relieve itching. noun an antipruritic drug. Origin: late 19th century: from anti- + pruritic (see pruritus)antipruritic in other Oxford dictionaries Definition of antipruritic in the British & World English dictionary