antidromic Syllabification: (an·ti·drom·ic)Pronunciation: /ˌantiˈdrämik/Definition of antidromic adjective Physiology (of an impulse) traveling in the opposite direction to that normal in a nerve fiber. The opposite of orthodromic.Origin: early 20th century: from anti- + Greek dromos 'running' + -icantidromic in other Oxford dictionaries Definition of antidromic in the British & World English dictionary