ampicillin Syllabification: (am·pi·cil·lin)Pronunciation: /ˌampiˈsilin/Definition of ampicillin noun Medicine a semisynthetic form of penicillin used chiefly to treat infections of the urinary and respiratory tracts. Origin: 1960s: blend of amino and a contraction of penicillinampicillin in other Oxford dictionaries Definition of ampicillin in the British & World English dictionary