amitriptyline Syllabification: (am·i·trip·ty·line)Pronunciation: /ˌamiˈtriptəˌlēn, -lin/Definition of amitriptyline noun Medicine an antidepressant drug of the tricyclic group, with a mild tranquilizing action. Origin: 1960s: from ami(ne) + tri- + (he)ptyl + -ine4amitriptyline in other Oxford dictionaries Definition of amitriptyline in the British & World English dictionary