Wye Syllabification: (Wye)Pronunciation: /wī/Definition of Wye a river that rises in the mountains of western Wales and flows southeast for about 132 miles (208 km) before entering the Severn estuary at Chepstow. In its lower reaches it forms part of the border between Wales and England. Wye in other Oxford dictionaries Definition of Wye in the British & World English dictionary