Definition of Salem
1an industrial city in Tamil Nadu in southern India; population 872,400 (est. 2009). 2the state capital of Oregon, on the Willamette River, southwest of Portland; population 153,435 (est. 2008). 3a city and port in northeastern Massachusetts, on the Atlantic coast, north of Boston; population 41,256 (est. 2008). First settled in 1626, it was the scene in 1692 of a notorious series of witchcraft trials. 4a town in southeastern New Hampshire, southeast of Derry; population 29,414 (est. 2008).