Orinoco Syllabification: (Or·i·no·co)Pronunciation: /ˌôrəˈnōkō/Definition of Orinoco a river in northern South America that rises in southeastern Venezuela and flows 1,280 miles (2,060 km), entering the Atlantic Ocean through a vast delta. For part of its length it forms the border between Colombia and Venezuela. Orinoco in other Oxford dictionaries Definition of Orinoco in the British & World English dictionary