Origen Syllabification: (Or·i·gen)Pronunciation: /ˈôriˌjen, ˈär-/Definition of Origen (circa 185-circa 254), Christian scholar and theologian, probably born in Alexandria, Egypt. His most well-known work was the Hexapla, an edition of the Old Testament with six or more parallel versions. Origen in other Oxford dictionaries Definition of Origen in the British & World English dictionary